Integration and standardization of intrinsically disordered protein data

Intrinsically disordered proteins (IDPs), characterized by high conformational variability, cover almost a third of the residues in Eukaryotic proteomes. As major players in cellular regulation, IDPs are involved in numerous diseases. Specialized IDP databases provide a starting point for analysis, yet their integration into core databases remains very limited. Here, we propose to start integrating IDP information into ELIXIR core data resources. This will be achieved with a three pronged approach: (1) Integration of an expanded version of MobiDB-lite into UniProtKB and PDBe including links back to MobiDB via the InterPro infrastructure. (2) Creation of a minimal information about IDP experiments (MIADE) standard and data interchange format will help ensure interoperability between databases with manually curated IDP data. (3) Sustainability of curated IDP data will be enhanced by creating PubDisProt, a new deposition resource for linking curated literature and protein identifiers across databases.

Duration: 

1 June 2018 to 31 May 2019

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