This kickoff meeting will discuss a recently approved ELIXIR User Community on the topic of Intrinsically Disordered Proteins (IDPs).
Over the last two decades, IDPs have developed from being a pet project of biophysicists interested in protein (non-)folding to being recognized as a major determinant in cellular regulation. It is estimated that almost half of the human proteome is made up of “dark” residues mostly encoding for IDPs and related phenomena with IDPs having central roles for protein homeostasis, cellular signaling and implicated in many human diseases. One of the key problems with IDPs, and the main limitation why their existence is not yet translated into the ELIXIR core data resources, was the lack of a clear definition of the phenomenon. In a way, the concept of intrinsic disorder is itself disordered, as different authors have used it to mean somewhat different things.
ELIXIR User Community coordinate ELIXIR’s activities by bringing together experts to develop specialised standards, services, workshops and Implementation Studies in the domains of Human Data, Rare Diseases, Marine Metagenomics, Plant Sciences, Proteomics, Metabolomics and Computational resources. IDP User Community would drive the integration of data from (un-)structural biology into the core data resources and would provide new standards, technology and training to develop the field.
Full details including the Participants list and Preliminary schedule can be found here.